The most common side effects are nausea or abdominal discomfort. I hope it settles down for you and works well for your RA. What should I watch for? This medicine can make you more sensitive to the sun. The most common side effects include: Upset stomach; Diarrhea; Nausea/vomiting; Headache; Appetite loss; Skin sensitivity; Approximately 10% of patients taking Sulfasalazine experience a skin rash. All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Give as directed by your veterinarian. Fertility returns when the medicine is stopped. My husband started on sulfasalazine a week ago on two a day. Sulfasalazine is associated with few common side effects. These negative effects might evaporate as the body gets used to the medication. It can also cause your urine or skin to turn yellowish-orange; this effect is harmless. Sulfasalazine may cause blood problems. Possible Side Effects. and the drug was replaced after a … The Sulphasalazine is a DMARD and this can effect the white blood cells, sometimes they will withdraw the Dmard and try another one. Certainly it went away when i stopped taking it. Abdominal issues seem to resolve over time, especially when the drug is given at a low dose initially. !!! He has decided to stay on the same dose rather than increase it to see if it stabilises. Dental work should be delayed until your blood counts have returned to normal. Therefore, you should be careful when using regular toothbrushes, dental floss, and toothpicks. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. You will need frequent blood and urine checks. Sulfasalazine is given by mouth and is used off label to treat inflammatory large bowel disease and vasculitis. It is best to take this medicine right after meals, at evenly spaced times throughout the day and night. In rheumatoid arthritis, the effect of sulfasalazine delayed release tablets can be assessed by the degree of improvement in the number and extent of actively inflamed joints. Side effects include dry eye, decreased appetite, vomiting, yellowing of the skin, eyes, or body fluids. The contraindications are textbook I understand , although I am not a GP or specialist. But I think it must be - after all, side effects are only known by getting feedback from the people using the drug. Try not to let more than 8 … xx Visit your doctor or health care professional for regular checks on your progress. Oh, my GP said the itching wasnt a side effect of sulfazal. When taking Sulfasalazine, reported side effects are usually mild and improve in time. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. 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